Table 1 SH-SY5Y cells were serum-starved in the absence or presence of 1 μM wild-type α-Syn or α-Syn(A53T) for indicated time periods.

From: Extracellular α-synuclein induces sphingosine 1-phosphate receptor subtype 1 uncoupled from inhibitory G-protein leaving β-arrestin signal intact

Conditions

Apoptotic cells

18 hr%

48 hr%

Serum-starved

1.47 ± 0.24

3.36 ± 0.33

α-Syn (serum-starved)

1.18 ± 0.45

3.09 ± 0.57

α-Syn(A53T) (serum-starved)

1.17 ± 0.46

3.02 ± 0.22

  1. Chromatin condensation during apoptosis was detected by 4,6-diamidino-2-phenylindole-2-HCl (DAPI) staining. Data are mean ± s.e.m. of 3 independent experiments. No significant difference was seen between the treatments.
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