Figure 4: Transdifferentiation of TSCs and MSCs in vivo.
From: Cardiac repair in a mouse model of acute myocardial infarction with trophoblast stem cells
(A) Confocal imaging of the TSCs-engrafted hearts and fluorescent immunostaining for α-actinin demonstrated evidence for cardiomyocytes differentiation; nuclei were counterstained with DAPI. (B,C) The sections displayed in B and C showed that MSCs and TSCs gave rise to endothelial-like cells by CD31-staining and participated in the formation of the vasculature as assessed by vWF staining in vivo. The arrows in B identifies co-staining of GFP and CD31. The boxed region in C is shown at higher magnification in the right panel. n = 6 for each group.
