Figure 2: Effect of Clozapine N-Oxide (CNO) on genioglossal muscle activity in mice treated with DREADDs. | Scientific Reports

Figure 2: Effect of Clozapine N-Oxide (CNO) on genioglossal muscle activity in mice treated with DREADDs.

From: Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency

Figure 2

(A) Representative genioglossal electromyography (EMGGG), moving average (∫EMGGG) and respiratory effort recorded at baseline (left) and after CNO administration (right). Note the robust increase in both phasic and tonic EMG activity after CNO. (B) EMG response to CNO or saline in the same DREADD treated animals (n = 13; 15 minutes after injections) and EMG response to CNO in mice treated with control virus (n = 6, 15 minutes after injection) normalized to peak phasic EMG at baseline. a.u. arbitrary units. *, p < 0.001.

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