Figure 3: Effect of Clozapine N-Oxide (CNO) on upper airway patency by MRI in mice treated with DREADDs.
From: Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency
Representative MR (A) and schematic (B) sagittal images show dilatation of the upper airway after CNO treatment. (C) The cross sectional area of the pharynx on axial images 4 mm caudal to the hard-soft palate junction (red lines on panel B) before and after treatment with CNO (n = 6) show significant dilatation of the pharynx during inspiration and expiration, whereas saline (n = 3) had no effect. *p < 0.05. (B) Brain; H/S, the hard/soft palate junction; N, nasopharynx; O, oropharynx. Credit: Publisher shall credit the image as such: Illustration by Corinne Sandone, © 2016 Johns Hopkins University, used with permission.
