Figure 6: The graphical abstract of chemically induced human MSCs from fibroblasts.
From: Efficient Generation of Chemically Induced Mesenchymal Stem Cells from Human Dermal Fibroblasts
The chemical cocktail with six chemical inhibitors with or without three growth factors efficiently and robustly generated iMSCs from primary dermal fibroblasts in six days. iMSCs are multipotent and can further differentiate into osteoblasts (bone lineage), adipocytes (fat lineage), and chondrocytes (cartilage lineage). iMSCs also markedly increased the clonogenicity and decreased the fatality of endotoxin-induced acute lung injury in a mouse model.
