Table 1 Differentially expressed proteins between normal, degenerated and regenerating zebrafish retina as identified by mass spectrometry.

From: Comparison of proteomic profiles in the zebrafish retina during experimental degeneration and regeneration

Protein Class

Accession

Protein name

Peptide count

Fold change

D/N

R/N

R/D

Calcium binding protein

Q6XG62

Ictacalcin

6

1.21

3.90

3.22

Cell adhesion molecule

E9QFY9

Galectin

3

5.02

1.64

0.33

Cytoskeletal

F1QKY8

Tubulin, beta 2A class IIa

91

0.56

44.24

79.16

Q6NW90

Tubulin beta 5

138

0.51

4.04

7.85

F1QCY2

Tubulin alpha 8 like 3

107

3.47

0.13

0.037

F1QAM8

Vimentin

5

0.35

2.59

7.33

F1RCB6

Actin

75

2.27

1.73

0.76

Q5XTP0

Crystallin gamma S1

3

4.21

0.59

0.14

Q52JI4

Beta B2 crystallin

10

2.26

0.60

0.27

Q6P3K5

Krt5 protein

2

1.97

2.01

1.02

Kinase/ Transferase

Q68EH2

Adenylate kinase isoenzyme 1

2

2.00

0.54

0.27

Q50LC6

Glutathione S transferase pi 2

14

2.12

0.73

0.34

Nucleic acid binding

F1Q912

Predicted: Transcription co-factor

2

7.96

0.71

0.089

Q3B7P7

Ubiquitin A 52 residue ribosomal protein fusion product 1

54

1.32

4.17

3.16

DNA binding

G1K2L0

Histone H2B

52

4.76

0.76

0.16

Q6DH91

Histone H2B

16

1.47

4.41

3.00

F1QIH4

Histone H2B

67

1.78

2.28

1.28

Signalling molecule

Q7ZVG7

Fibrinogen gamma polypeptide

109

13.05

0.74

0.056

Q6NYE1

Fibrinogen B beta polypeptide

90

6.32

0.99

0.16

B8A5L6

Fibrinogen alpha chain

93

6.70

1.30

0.19

Glycolipoprotein

F1QV15

Vitellogenin 6

51

32.12

1.28

0.04

F1R887

Vitellogenin 4

52

0.09

2.50

28.83

Q1MTC4

Vitellogenin 2

6

4.55

1.07

0.23

Q1LWN2

Vitellogenin 1

60

8.60

0.32

0.04

Apolipoprotein

E7FES0

Apolipoprotein A-Ib

32

7.00

0.77

0.11

B3DFP9

Apolipoprotein A-II

16

6.11

0.84

0.14

E9QDI1

Apolipoprotein C-I like

12

3.88

0.73

0.19

Transport proteins

B8JL43

Serotransferrin

8

5.58

1.23

0.22

Q66I80

Fatty acid binding protein 11a

27

2.25

0.78

0.35

I3ISI4

Predicted: fatty acid binding protein 3

10

0.80

2.81

3.53

Q9I8N9

Brain type fatty acid binding protein

36

0.66

4.82

7.35

Q6P603

Annexin A2A

12

6.70

3.34

0.50

  1. Table shows proteins which exhibited 2-fold increase in expression in the degenerating as compared to normal retina as well as those in the regenerating over normal and degenerated retina.
  2. (Numbers in Bold = 2-fold or more upregulated; Numbers in italics = 0.5-fold or less downregulated). N = normal retina; D = degenerated retina; R = regenerating retina.
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