Figure 1: Identification of FLC samples in The Cancer Genome Atlas (TCGA). | Scientific Reports

Figure 1: Identification of FLC samples in The Cancer Genome Atlas (TCGA).

From: Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma

Figure 1

(a) Six FLC samples were identified in TCGA by RNA expression of DNAJB1-PRKACA. While all six samples were annotated as Liver Hepatocellular Carcinoma (LIHC), three were subannotated as FLC and 3 were subannotated as HCC. These three samples were examined further using whole exome sequencing, SNP array (to validate the chromosome 19 deletion resulting in DNAJB1-PRKACA), histology, and patient ages. (b) Sample histology images from the three annotated FLC samples and three misannotated HCC samples, all of which express DNAJB1-PRKACA. Arrowheads depict intratumoral fibrotic bands and arrows depict distinct nuclei with prominent nucleoli characteristic of FLC tumor cells. (c) Density plot depicting the age distribution of annotated FLC, misannotated HCC, annotated HCC, and CCA patients in TCGA. Dotted lines represent the mean age of each group.

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