Table 1 Antiviral activity of IDPP to different HCV genotypes.

From: A Novel Inhibitor IDPP Interferes with Entry and Egress of HCV by Targeting Glycoprotein E1 in a Genotype-Specific Manner

Virus strain (Core-NS2)a

Genotype

E1 (257aa)b

EC50 [μM]c

JFH1_AB047639

2a

G

0.00006

Jc1 (J6/JFH1)

2a

G

0.004

J8 (J8/JFH1)

2b

S

0.05

TN

1a

Q

>1

S52

3a

S

>1

ED43

4a

S

>1

SA13

5a

P

>1

HK6a

6a

T

>1

QC69

7a

D

>1

  1. aGiven virus strains refer to PubMed (DDBJ/EMBL/GenBank accession no AB047639).
  2. Various HCV chimeras were utilized to determine EC50 values28.
  3. bAmino acid at position 257 in E1.
  4. cEC50 values determined by dose–response curve analysis using Prism v5.0 software (Graph Pad Software, Inc., La Jolla, CA).
Back to article page