Figure 6: Dysfunction of IL-5-induced angiogenesis ex vivo and in vivo in HSP70-1 knockout mice (KO).
From: HSP70-1 is required for interleukin-5-induced angiogenic responses through eNOS pathway
(a) Aortic ring assay was performed in wild type (WT) and HSP70-1 knockout mice (KO) at 9 days. (b) Quantitative analysis of microvessel sprouting in aortic rings. (c) Matrigel plug in vivo assay in wild type (WT) and HSP70-1 knockout mice (KO) at 7 days. (d) Quantification of hemoglobin contents. (e) The matrigel plugs were immunostained with antibody against CD31. (f) Determination of the area of CD31-positive vessels. All data are reported as the means ± SE from three independent experiments. *P < 0.05 compared with control, #P < 0.05 compared with IL-5 treatment in WT.
