Figure 8: Proposed model to illustrate the mechanism of increased COX-2 expression and PGE2 production during DENV infection. | Scientific Reports

Figure 8: Proposed model to illustrate the mechanism of increased COX-2 expression and PGE2 production during DENV infection.

From: Cyclooxygenase‐2 facilitates dengue virus replication and serves as a potential target for developing antiviral agents

Figure 8

DENV infection induces COX-2 expression through activation of the NF-κB and MAPK/JNK-mediated C/EBP signaling pathways. Phosphorylated NF-κB and activated C/EBP are translocated into the nucleus and bind to the COX-2 promoter region. COX-2 induction and elevated PGE2 production by DENV infection lead to enhanced activity of the viral polymerase and viral propagation.

Back to article page