Figure 7

Relationship between pre-challenge HAI or IgG titers and measured clinical parameters after infection. Relationship between pre-challenge HAI or vaccine-specific IgG antibodies with (A,D) cumulative viral load in the nasal washes (NW), (B,E) weight loss and (C,F) cumulative symptom score. The total viral load were derived from Area-Under-the Curve (AUC) calculations in Fig. 2D. Cumulative symptom scores were tabulated in Table S1 over the 7 study-days. Ferrets that were euthanized were allocated the maximum score of 13 on days indicated with an E in Table S1. The area shaded in gray in (F) indicates ferrets that were euthanized. Individual ferrets are assigned its respective symbol within its vaccine group (colored as ○ for naïve, ● for unadjuvanted, for MF59 and
for AS03).