Figure 7 | Scientific Reports

Figure 7

From: The immune correlates of protection for an avian influenza H5N1 vaccine in the ferret model using oil-in-water adjuvants

Figure 7

Relationship between pre-challenge HAI or IgG titers and measured clinical parameters after infection. Relationship between pre-challenge HAI or vaccine-specific IgG antibodies with (A,D) cumulative viral load in the nasal washes (NW), (B,E) weight loss and (C,F) cumulative symptom score. The total viral load were derived from Area-Under-the Curve (AUC) calculations in Fig. 2D. Cumulative symptom scores were tabulated in Table S1 over the 7 study-days. Ferrets that were euthanized were allocated the maximum score of 13 on days indicated with an E in Table S1. The area shaded in gray in (F) indicates ferrets that were euthanized. Individual ferrets are assigned its respective symbol within its vaccine group (colored as for naïve, for unadjuvanted, for MF59 and for AS03).

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