Table 1 Frequency of amino acid substitutions in HBV/RT in the viral quasi species pool from LMV-failed (n = 16) and treatment-naïve (n = 14) CHB patients.
Amino acid substitutions in HBV/RT | Frequency (%) in HBV clonal population in LMV-failed CHB patients (total no of clones = 160) | Frequency (%) in HBV clonal population in treatment naïve-CHB patients (total no of clones = 140) | p-value (unadjusted) | Benjamini- Hochberg threshold | |
|---|---|---|---|---|---|
rtM204V | Known LMV- resistant mutations | 26.3 | 0 | 2.05E-13* | 0.000363 |
rtM204I | 15.6 | 0 | 1.12E-07* | 0.001962 | |
rtS202G | 17.5 | 0 | 1.12E-08* | 0.00116 | |
rtL80I | 15.6 | 0 | 1.12E-07* | 0.001962 | |
rtL180M | 26.3 | 0 | 2.05E-13* | 0.000363 | |
rtN53D | Novel amino acid substitutions | 39.4 | 20 | 3.00E-04* | 0.002326 |
rtY54H | 43.1 | 27.1 | 5.30E-03 | 0.002616 | |
rtL91I | 8.8 | 0 | 1.00E-04* | 0.00218 | |
rtI121L | 24.4 | 0 | 2.19E-12* | 0.000436 | |
rtF/H122L | 42.5 | 14.3 | 6.56E-08* | 0.001599 | |
rtH124N | 48.8 | 12.9 | 1.88E-11* | 0.000727 | |
rtQ130P | 41.9 | 11.4 | 2.86E-09* | 0.001017 | |
rtN131D | 50.6 | 15.7 | 1.27E-10* | 0.000872 | |
rtA219S | 94.4 | 82.1 | 9.00E-04* | 0.002471 | |
rtH248N | 78.8 | 56.4 | 4.00E-05* | 0.002035 | |
rtS256C | 89.4 | 80.7 | 4.88E-2 | 0.002762 | |
rtR266I | 90.6 | 64.3 | 4.39E-08* | 0.001453 | |
rtH/L267Q | 92.5 | 67.1 | 2.48E-08* | 0.001308 | |
rtV278I | 50 | 12.9 | 4.06E-12* | 0.000581 | |
