Table 2 Frequency of amino acid substitutions in HBV/S in the viral quasi species pool from LMV-failed (n = 16) and treatment-naïve (n = 14) CHB patients.
Amino acid substitutions in HBV/S | Location in Non-epitope/Epitope region) | Frequency (%) in HBV clonal population in LMV-failed CHB patients (total no of clones = 160) | Frequency (%) in HBV clonal population in treatment-naïve CHB patients (total no of clones = 140) | p-value (unadjusted) | Benjamini- Hochberg threshold |
|---|---|---|---|---|---|
sN3S | non-epitope | 22.5 | 12.1 | 2.26E-02 | 0.004535 |
sI4T | non-epitope | 23.8 | 12.1 | 1.09E-02 | 0.003319 |
sS45A | B-, Th-, Tc-cell epitope | 26.9 | 14.3 | 1.02E-02 | 0.003097 |
sV47T | B-, Th-, Tc-cell epitope | 20 | 8.6 | 5.40E-03 | 0.002876 |
sL49P | B-, Th-, Tc-cell epitope | 23.1 | 12.1 | 1.58E-02 | 0.004093 |
sS53L | non-epitope | 23.1 | 12.1 | 1.58E-02 | 0.004093 |
sA/S113T | non-epitope | 22.5 | 12.1 | 2.26E-02 | 0.004535 |
sT114S | non-epitope | 85.6 | 69.3 | 7.68E-04* | 0.002323 |
sT118V | B-cell epitope | 30.6 | 17.9 | 1.10E-02 | 0.00354 |
sT126I | B-, Th-cell epitope | 19.4 | 5.0 | 1.90E-04* | 0.00177 |
sP127T | B-, Th-cell epitope | 61.3 | 34.3 | 3.45E-06* | 0.001106 |
sA128V | B-, Th- cell epitope | 32.5 | 17.9 | 5.21E-03 | 0.002655 |
sN131T | B-, Th- cell epitope | 90.6 | 69.3 | 3.68E-06* | 0.001327 |
sN143S | B-, Th- cell epitope | 85.6 | 69.3 | 7.68E-04* | 0.002323 |
sK160R | B-cell epitope | 25.6 | 12.1 | 3.36E-03 | 0.002434 |
sY/S161F | B-cell epitope | 87.5 | 62.9 | 7.34E-07* | 0.000664 |
sA194V | B-, Tc- cell epitope | 85 | 62.1 | 9.64E-06* | 0.001549 |
sI195M | B-cell epitope | 25 | 0 | 9.98E-13* | 0.000221 |
sW196L | B-cell epitope | 14.4 | 0 | 2.46E-07* | 0.000442 |
sR210N | Tc epitope | 25 | 5.7 | 3.19E-06* | 0.000885 |
