Table 1 Track-HD and Leiden cohorts for RNA-Seq analysis.

From: Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s disease

Cohort

Group

n

Mean age, y ± SD (range)

Gender (male/female)

Mean (CAG)n length ± SD (range)

Mean TMS ± SD (range)

Mean TFC ± SD (range)

Track-HD

Premanifest

50

42 ± 9 (22–64)

24/26

43 ± 3 (39–52)

2 ± 2 (0–8)

13 ± 0 (12–13)

Manifest

62

48 ± 10 (23–64)

26/36

44 ± 3 (39–59)

23 ± 11 (5–45)

11 ± 2 (7–13)

HD

112

46 ± 10 (22–64)

50/62

44 ± 3 (39–59)

14 ± 13 (0–45)

12 ± 2 (7–13)

Control

22

45 ± 5 (34–53)

9/13

—

—

—

Leiden

Premanifest

18

46 ± 10 (29–63)

5/13

42 ± 2 (39–47)

3 ± 2 (0–5)

12 ± 1 (10–13)

Manifest

56

55 ± 11 (35–79)

29/27

44 ± 3 (39–53)

42 ± 30 (6–102)

7 ± 5 (0–13)

HD

74

53 ± 11 (29–79)

34/40

44 ± 3 (39–53)

32 ± 31 (0–102)

8 ± 5 (0–13)

Control

27

43 ± 11 (26–65)

13/14

—

—

—

Combined

HD

186

48 ± 11 (22–79)

84/102

44 ± 3 (39–59)

21 ± 24 (0–102)

10 ± 4 (0–13)

Control

49

44 ± 9 (26–65)

22/27

—

—

—

  1. Manifest subjects demonstrated motor abnormalities that were unequivocal signs of HD. Premanifest gene carriers had a total motor score of 5 or lower and a diagnostic confidence score (DCS) less than 4 on the UHDRS, indicating no substantial motor signs. The HD group consists of the combined premanifest and manifest subjects. Controls were matched for age and gender. Age and clinical scores considered for the analysis were at time of blood collection. SD – standard deviation; TFC – Total Functional Capacity; TMS – Total Motor Score.
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