Table 5 Brain expression modules significantly dysregulated both in HD brain and HD blood.

From: Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s disease

Module number

Brain Region

Module name

Number of genes

p (combined)

p (TRACK)

p (Leiden)

cor (HD brain)

p (HD brain)

Description

69

FC_BA4

FC4pos1

712

3.77E-08

3.05E-05

1.32E-03

0.610

3.77E-03

Inflammatory response

48

CN

CNpos2

1785

2.03E-07

3.85E-03

6.33E-03

0.724

2.21E-11

Lipid metabolism/regulation of transcription

64

CN

CNpos6

114

3.13E-04

1.18E-02

3.80E-02

0.463

2.28E-04

Inflammatory response

66

CN

CNneg1

2644

2.71E-07

1.51E-04

2.13E-02

−0.800

6.03E-15

Synapse

  1. All modules in this table are significantly dysregulated after correction for multiple testing (q < 0.05) in the combined blood sample, and are nominally significantly dysregulated (p < 0.05) in both Track-HD and Leiden datasets separately. Cor(HD brain) – the correlation between module eigengene and HD status observed by Neueder and Bates30 in brain expression data, with a positive correlation corresponding to upregulation in HD. p(HD brain) is the p-value for that correlation (corrected for multiple testing of modules).
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