Table 1 Upstream Regulators.

From: Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients

Cell Phenotype

Upstream Regulator

Exp Fold Change

Molecule Type

Predicted Activation State

Activation z-score

p-value of overlap

Epithelioid

PPARG

2.32

ligand-dependent nuclear receptor

Activated

2.69

6.86E-04

CDH1

−2.54

other

Inhibited

−1.59

1.25E-02

Non-Epithelioid

IL1B

15.27

cytokine

Activated

2.95

7.79E-30

MMP3

9.08

peptidase

Activated

2.19

4.47E-01

F2R

4.46

g-protein coupled receptor

Activated

2.78

6.05E-06

PTGS2

4.03

enzyme

Activated

3.01

1.23E-09

SPP1

3.57

cytokine

Activated

3.40

3.72E-07

ITGA2

3.08

transmembrane receptor

Activated

2.43

6.28E-04

FGF2

2.93

growth factor

Activated

2.64

4.55E-19

IL1A

2.73

cytokine

Activated

4.73

1.02E-10

ADORA2B

2.57

g-protein coupled receptor

Activated

2.34

5.42E-05

NRIP1

2.53

transcription regulator

Activated

2.38

4.39E-03

SNAI1

2.41

transcription regulator

Activated

2.25

3.92E-07

TGFB2

2.23

growth factor

Activated

2.09

5.88E-08

HMGB1

2.01

transcription regulator

Activated

3.08

5.35E-03

WNT4

−4.56

cytokine

Inhibited

−2

1.03E-04

GHR

−2.11

transmembrane receptor

Inhibited

−2.19

1.47E-02

CDH1

−11.24

other

Inhibited

−2.87

1.43E-07

  1. Table columns (left to right): Cell phenotype; Upstream regulator genes; Gene’s fold change determined in microarray analysis; Molecule type; Predicted activation state of upstream regulator; Z-score: if z-score ≥ 2 then upstream regulator is activated, and if z-score ≤ −2 then is inhibited; p-value, calculated by Fisher’s Exact Test, indicates the statistical significance of genes in the data set that are downstream of de upstream regulator. Normal letter: up-regulated genes; bold: down-regulated genes in microarrays.
Back to article page