Figure 3: ASIC currents in cultured and acute isolated rat cardiomyocytes. | Scientific Reports

Figure 3: ASIC currents in cultured and acute isolated rat cardiomyocytes.

From: Multiple H+ sensors mediate the extracellular acidification-induced [Ca2+]i elevation in cultured rat ventricular cardiomyocytes

Figure 3

(a) Representative ASIC-like currents inhibited by amiloride (100 μM, n = 3 cells) and PcTx1 (10 nM, n = 4 cells) in cultured rat cardiomyocytes. (b) Inhibition of ASIC-like currents by amiloride (100 μM, n = 3 cells) in acute isolated myocardiocytes of adult rat. (c) pH-dependent (upper) and pH-current density curve (lower) of ASIC currents in cultured rat cardiomyocytes. “—” indicates the duration of pH = 7.0, 6.0, 5.0 or 4.0 from 7.4. pH 7.0: 8.51 ± 4.37 pA/pF (n = 8 cells), pH 6.0: 17.03 ± 5.02 pA/pF (n = 11 cells), pH 5.0: 50.20 ± 6.94 pA/pF (n = 7 cells), pH 4.0: 53.73 ± 9.87 pA/pF (n = 7 cells). Each point represented as the mean ± s.e.m.

Back to article page