Figure 4: Ndufs4 cKO mice show progressive memory loss in the novel object recognition assay. | Scientific Reports

Figure 4: Ndufs4 cKO mice show progressive memory loss in the novel object recognition assay.

From: Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson’s disease-like non-motor symptoms without loss of dopamine neurons

Figure 4

(a–h) Ndufs4 cKO and littermate control mice were tested for the novel object recognition assay at 3 months and then again at 6 months of age. The same cohort of mice was subjected to both 1-h and 24-h memory tests on two different days using different sets of objects. (a,b)Training and 1 h memory test in 3-month-old mice. (c,d) Training and 24-h memory in 3-month-old mice. (e,f) Training and 1-h memory in 6-month-old mice. (g,h) Training and 24-h memory in 6-month-old mice. n = 7–10 mice/genotype. (i–p) Ndufs4 cKO and littermate control mice were tested for the short-term spatial memory using the novel object location test at 3 months and then again at 6 months of age. Mice were subjected to both 1-h and 24-h memory tests on two different days. (i,j) Training and 1-h test using 3-month-old mice. (k,l) Training and 24-h test using 3-month-old mice. (m,n) Training and 1-h test using 6-month-old mice. (o,p) Training and 24-h test using 6-month-old mice. n = 7–10 mice/genotype. *p < 0.05; **p < 0.01; ***p < 0.001.

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