Figure 5: Ndufs4 cKO mice show impaired spatial learning and memory in the reversal Morris water maze test. | Scientific Reports

Figure 5: Ndufs4 cKO mice show impaired spatial learning and memory in the reversal Morris water maze test.

From: Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson’s disease-like non-motor symptoms without loss of dopamine neurons

Figure 5

(a) Target (in quadrant 1) acquisition in the hidden platform, quantified as swim distance to platform, was similar in control and Ndufs4 cKO mice. (b) Both control and Ndufs4 cKO mice spent more time in the virtual target quadrant (quadrant 1) in the probe test conducted 24 h after training, suggesting that they retained the spatial memory. (c) Swim distance to escape in the reverse hidden platform training where the hidden platform was moved to quadrant 3. Ndufs4 cKO mice swam longer distances to locate the platform, suggesting impaired learning of newer spatial information. (d) Ndufs4 cKO mice spent less time in the virtual target quadrant (quadrant 3) than control mice during the reversal probe test. (e) The ratio of time spent in Q3 versus Q1 in the reversal probe test was significantly lower for cKO mice than control mice. (f) Control and cKO mice performed equally well in the visible platform test; they showed comparable latency to reach the platform. *p < 0.05; **p < 0.01; ***p < 0.001; n.s. not statistically significant.

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