Figure 3: Information gain from multi-region copy number profiling in patients with colorectal cancer.
From: Detecting truly clonal alterations from multi-region profiling of tumours
Copy number changes were inferred from spatially distributed single glands of 11 colorectal tumours. Based on the shape of the universal curve (Equation (8)), 7 tumours appear balanced or nearly balanced and 4 tumours appear unbalanced. Balanced tumours require fewer samples to identify truly clonal copy number changes, whereas uncertainty remains high in unbalanced trees. Data from Sottoriva et al.23.
