Figure 3: NC prevented abnormal spontaneous diastolic Ca2+ waves promoted in cardiomyocytes by repeated-dose administration of free LYC.
From: Biodegradable Polymeric Nanocapsules Prevent Cardiotoxicity of Anti-Trypanosomal Lychnopholide
(A and B) Representative traces of spontaneous Ca2+ waves during resting periods following a train of stimulation in cardiomyocytes from Ctrl, LYC, NC and LYC-NC groups after 20 days of treatment, under basal (A) and acute stress conditions (Iso 10 nM) (B). (C) Effect of 20 days of each treatment on the percentage of cardiomyocytes developing at least one spontaneous Ca2+ wave. *p < 0.05, LYC vs. other groups under the same conditions; ‡p < 0.05, vs. Ctrl under the same conditions; #p < 0.05, basal vs. stress condition; 20–30 cells per group.
