Figure 6: Acute exposure to LYC promoted spontaneous Ca2+ sparks.
From: Biodegradable Polymeric Nanocapsules Prevent Cardiotoxicity of Anti-Trypanosomal Lychnopholide
(A) Typical line-scan confocal images of Ca2+ sparks in Fluo-4-AM-loaded cardiomyocytes from mice treated with vehicle (Ctrl) or LYC (14 nM), in the presence or absence of Iso (10 nM). (B) Mean frequency of Ca2+ sparks measured under the different experimental conditions. (C) Averaged SR Ca2+ content in the different experimental conditions estimated from the caffeine-induced massive release of SR Ca2+ (expressed as the ratio of fluorescence at 405 and 480 nm); *p < 0.05, LYC 14 nM vs. Ctrl under the same condition; #p < 0.05, basal vs. stress condition; 30–35 cells per group.
