Figure 2: Effects of the 1000 Genomes lead variants for all novel and known loci.
From: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function
Shown are the effect sizes and minor allele frequencies (MAF) of the 1000 Genomes lead variants (variants with smallest p-value) in each of the 10 novel (blue), the 39 known genome-wide significant loci (green), and the 14 known loci that were not genome-wide significant in this analysis (orange). Additionally, the 80% power to detect such effects in a sample size of 110,000 subjects (as in this 1000 Genomes meta-analysis) is shown as a red line. A known locus is defined by the published lead variant ±1 Mb; a novel locus is defined by the 1000 Genome lead variant ±1 Mb.
