Table 1 IC50 values of HDAC1-3-selective inhibitor MS-275 and pan-HDAC inhibitor SAHA for recombinant human HDAC1-3, HDAC 6 and HDAC 8.

From: HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice

 

HDAC 1

HDAC 2

HDAC 3

HDAC 6

HDAC 8

MS-275

0.19 ± 0.04

0.41 ± 0.09

0.95 ± 0.19

≥100

76.5 ± 10.1

SAHAa

0.07 ± 0.01

0.16 ± 0.05

0.05 ± 0.02

0.06 ± 0.01

1.52 ± 0.46

  1. Data are presented as mean values (in μM) of 3 independent measurements ± SD. ND = not determined. aIC50 values for SAHA are taken from Szymanski et al.34.
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