Figure 5: TC-PTP deficiency confers a resistance against DMBA-induced apoptosis and an enhanced TPA-induced cell proliferation through the regulation of STAT3 and AKT signaling. | Scientific Reports

Figure 5: TC-PTP deficiency confers a resistance against DMBA-induced apoptosis and an enhanced TPA-induced cell proliferation through the regulation of STAT3 and AKT signaling.

From: Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development

Figure 5

(A) Western blot analysis of p-EGFR, p-STAT3, p-AKT, p-ERK1/2, cyclin D1, Bcl-xL, Bax in the epidermis from K14Cre.Ptpn2w/w and K14Cre.Ptpn2fl/fl mice after TPA treatment. Mice were sacrificed at the indicated time after TPA treatment and epidermal cell lysates were prepared. (B) Western blot analysis of p-EGFR, p-STAT3, p-AKT, p-ERK1/2, cyclin D1, Bcl-xL, Mcl-1 in primary keratinocytes from both genotypes after TPA treatment. Cells were collected at the indicated time after TPA treatment and total cell lysates were prepared.

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