Figure 5
From: Hybrid Core-Shell (HyCoS) Nanoparticles produced by Complex Coacervation for Multimodal Applications
SEM images of nanoparticles produced by different calorimetric profile (A–D). A (•)- Nps obtained performing an Isothermal at 35 °C for 5.5 h; B (□)- Result obtained performing an Isothermal at 40 °C. No demixing is observed; C (Х)- Result obtained performing an Isothermal at 28 °C until demixing (after 17 h). D (▴)-Result obtained performing an Isothermal at 23 °C until demixing (after 20 h). After that the demixing occurs, a ramp to 23 °C for 1.5 h is performed to complete the separation and to stabilize the morphologies. Morphological characterization of nanoparticles by TEM (E–F). Core-shell Gd-DTPA-Nps obtained without the use of the temperature profile collected in water. (E) Nps obtained at 0,1% wt/v HA, 1% wt/v Chitosan, 30% TPP wt/v, Gd-DTPA: Chitosan 1:1 and 8% v/v DVS and (F) Magnification of the previous image.
