Figure 1: Schisandrin A efficiently inhibits DENV replication in a dose-dependent manner. | Scientific Reports

Figure 1: Schisandrin A efficiently inhibits DENV replication in a dose-dependent manner.

From: Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway

Figure 1

(A) Structure of schisandrin A, schisandrin B, and schisandrin C. (B–D) Schisandrin A efficiently inhibits DENV RNA replication and protein synthesis. Huh-7 cells were infected with DENV for 2 h, followed by 0.1% of DMSO (dose 0, a negative control), 25, 30, 35, and 40 μM of schisandrin A, schisandrin B, or schisandrin C treatment for 3 days. The DENV RNA and protein levels were analyzed by RT-qPCR and Western blotting, respectively. For RT-qPCR, the DENV RNA level was normalized by the cellular gapdh mRNA level. The relative DENV RNA of each sample was presented as the % change compared to schisandrin A-untreated control (100%). For Western blotting, GAPDH served as an equal loading control. Error bars denote the means ± SD of five independent experiments (N = 5). *P < 0.05.

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