Figure 2: Schisandrin A inhibits replication of four serotypes of DENV. | Scientific Reports

Figure 2: Schisandrin A inhibits replication of four serotypes of DENV.

From: Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway

Figure 2

(A) Schisandrin A inhibits DENV titer. Huh-7 cells were infected by DENV at an MOI of 0.1 for 2 h and treated by 0.1% of DMSO (dose 0, a negative control), 25, 30, 35 and 40 μM schisandrin A. After 3 days treatment, the supernatant was collected, and the DENV titer was determined by plague assay. (B) Huh-7 cells were infected with the four DENV serotypes at an MOI of 0.1 for 2 h, followed by 0 (black bars), 30 (white bars), and 40 μM (gray bars) of schisandrin A treatment. The DENV RNA level was normalized by the cellular gapdh mRNA level in RT-qPCR. The relative DENV RNA of each sample was presented as the % change compared to schisandrin A-untreated control (100%). Error bars denote the means ± SD of five independent experiments (N = 5). *P < 0.05.

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