Figure 3: Schisandrin A protects ICR suckling mice from DENV infection. | Scientific Reports

Figure 3: Schisandrin A protects ICR suckling mice from DENV infection.

From: Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway

Figure 3

(A–D) Six-day-old ICR suckling mice were intracerebrally injected with heat-inactivated DENV (iDENV, blue line) or active DENV. DENV-infected mice received saline (DENV, blue line), 100 U/g IFN (DENV+IFN, green line), 5 (DENV+schisandrin A 5 mg/kg, yellow line) or 10 mg/kg (DENV+Schisandrin A 10 mg/kg, purple line) schisandrin A treatment every 2 days. Mice were sacrificed at 6 days postinfection, and the (A) clinical scores, (B) body weight, and (C) survival rates were measured daily. Disease severity was scored as follows: 0: no symptom, 1: slight losing weight and ruffled hair, 2: slowing of activity, 3: asthenia, 4: paralysis and mortally ill, and 5: death. (D) The brain tissue was collected to analyze the virus titer by plaque-forming assay. Each group included ten mice. Error bars denote the means ± SD. *P < 0.05.

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