Figure 7: Schisandrin A inhibits DENV replication in vivo through modulating IFN-mediated antiviral responses. | Scientific Reports

Figure 7: Schisandrin A inhibits DENV replication in vivo through modulating IFN-mediated antiviral responses.

From: Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway

Figure 7

(A,B) DENV-infected suckling mice were sacrificed at 6 dpi, and then the brain tissue was collected to determine (A) IFN-α-2, (B) IFN-α-5, (C) OAS1, (D) OAS2, (E) OAS3, and (F) PKR expression levels by RT-qPCR using specific primers. Gene expression was normalized by the cellular gapdh mRNA level. Filled circles, open circles, filled triangles and filled triangles indicate schisandrin A-untreated, IFN-treated, 5 or 10 mg/kg of schisandrin A-treated mice, respectively. Each group included ten mice. *P < 0.05.

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