Figure 6: PPARβ/δ mediated cerebral VSMC phenotypic switch and vascular remodeling in SAH rats, and ameliorated neurological deficits. | Scientific Reports

Figure 6: PPARβ/δ mediated cerebral VSMC phenotypic switch and vascular remodeling in SAH rats, and ameliorated neurological deficits.

From: PPARβ/δ, a Novel Regulator for Vascular Smooth Muscle Cells Phenotypic Modulation and Vascular Remodeling after Subarachnoid Hemorrhage in Rats

Figure 6

(A) Temporal profile and quantitative analysis of α-SMA and Smemb expression in the cerebral vessels within 5 days after SAH respectively (n = 6 rats per group). (B) Representative image and quantitative analysis of α-SMA, Smemb and PPARβ/δ expression in the cerebral vessels at 3 days after SAH after Ad-PPARβ/δ administration (n = 6 rats per group). (C) Immunohistochemistry of basilar artery with α-SMA (green), Smemb (red) and DAPI (blue) at 3 days after SAH after Ad-PPARβ/δ administration. (D) Quantitative analysis of the diameter and the wall thickness of basilar artery at 3 days after SAH after Ad-PPARβ/δ administration (n = 6 rats per group). (E) Modified Garcia test and beam balance in indicated groups at 3 days after SAH (n = 6 rats per group). All quantitative data were presented as mean ± standard deviation. Scale Bar = 50 μm (top) and 10 μm (bottom). *P < 0.05 vs. sham; ΔP < 0.05 vs. 6 hours after SAH; ##P < 0.05 vs. 12 hours after SAH. #P < 0.05 vs. SAH + Ad-PPARβ/δ.

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