Figure 1: Increased presence of adventitial lymphatic capillaries during human and mouse atherosclerosis development.
From: Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis
(A) Immunohistochemical staining of podoplanin+ (D2-40) lymphatic capillaries (Brown) in human aortic atherosclerotic lesions obtained during kidney transplantation (10x magnification, Insert = 20x magnification). *Shows CD31+ adventitial microvessels (blue). (B) Quantification of adventitial lymph vessel density (LVD) in different stages of human atherosclerotic lesion development. (C) Immunohistochemical staining of Lyve-1+ lymphatic capillaries (Purple) and CD31+ vasa vasorum (Blue) in mouse carotid atherosclerotic lesions. Continued line indicates the outer border of the media; the area between the continuous and dotted line indicates the adventitial area used for quantification (10x magnification, Insert = 20x magnification). (D) Quantification of the percentage Lyve-1+ lymphatic capillaries per adventitial area of different stages of mouse lesion development.
