Figure 2: Lymph node dissection results in an aggravation of plaque development in mice, characterized by an accumulation of CD3+ T cells within the vessel wall.
From: Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis
(A) Draining lymph node and efferent vessel were excised in the lymph node dissection group. (B) Percentage of CD45+ leukocytes in the adventitia of control and lymph node dissected (LD) mice. (C) Representative pictures of Hematoxylin-Eosin-stained sections of the carotid arteries from control and lymph node dissected mice. Quantification of (D) plaque volume, (E) plaque classification and (F) routine pathological examination of plaque composition. Percentage of Mac-3+ macrophages in the plaques (G). Percentage of CD3+ T cells in (H) plaque and (I) adventitia. (J) Percentage of Lyve-1+ lymphatic capillary area in the adventitia.
