Figure 4: The elimination of damaged mitochondria is impaired in 53BP1-deficient cells.
From: 53BP1 contributes to regulation of autophagic clearance of mitochondria
(A) Control and 53BP1-deficient U2OS cells were treated with 20 μM CCCP for 24 h and stained with MitoTracker Red CMXRos followed by mitochondrial mass analysis by flow cytometry. Representative histograms of mitochondrial fluorescence intensity are shown. (B) Fluorescence intensity of MitoTracker was quantified, and the percent change in mitochondrial mass was determined relative to the control. Results are shown as mean ± SD (n = 3), **P < 0.01.
