Figure 5: Correlation of two T cell signatures with clinical parameters. | Scientific Reports

Figure 5: Correlation of two T cell signatures with clinical parameters.

From: Tissue resident memory T cells in the human conjunctiva and immune signatures in human dry eye disease

Figure 5

(A) Upper panel: ocular redness; Lower panel: Ocular redness (OR) scores in controls (C) Cluster-1 patients with T cell signature-1 (1) and Cluster-2 patients with T cell signature-2 (2). (B) OR scores show a positive correlation with CD4+ TCM and CD8+ TCM; controls (blue); Cluster-1 patients with T cell signature 1 (red); dotted red line indicates OR 1.9. Pearson’s correlation coefficient was calculated for 55 subjects. Two-tailed P < 0.0001 for both the correlations. (C) Upper panel: Picture of ocular surface obtained with an Oculus Keratograph 5 M; Lower panel: NI-TBUT in controls (C) and Cluster-1 patients with immune signature-1 (1) and Cluster-2 patients (2). (D) NI-TBUT correlates with CD4+CD69−CD103+TEM-TRCM and CD8+CD69+CD103+ TEMRA-TRM; controls (blue); Cluster-2 patients with T cell signature-2 (red); dotted red line indicates NI-TBUT = 10 s. Pearson’s correlation coefficient was calculated for 49 subjects. Two-tailed P < 0.0001.

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