Figure 2: Analysis of social interaction, stereotyped and repetitive behavior in female and male BTBR mice. | Scientific Reports

Figure 2: Analysis of social interaction, stereotyped and repetitive behavior in female and male BTBR mice.

From: Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder

Figure 2

(A) Three-chamber social interaction test showing time spent in each chamber by BTBR and C57 mice of both sexes (n = 12/group; p = 0.7424 for chamber, p = 0.0077 for strain, p = 0.7761 for sex, p < 0.0001 for chamber x strain and p = 0.1671 for chamber x strain x sex, by three-way ANOVA). (B) Number of buried marble by BTBR and C57 mice of both sexes after a 30 min testing session (n = 12/group; p < 0.0001 for strain, p = 0.1322 for sex and p = 0.2689 for strain x sex, by two-way ANOVA). (C) Seconds spent in repetitive grooming measured for BTBR and C57 mice of both sexes during 10 min test session (n = 12/group; p < 0.0001 for strain, p = 0.0372 for sex, and p = 0.0269 for strain x sex, by two-way ANOVA). Significant differences are indicated by *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 using Bonferroni post-hoc tests following three-way ANOVA with chamber, strain and sex as factors (A) or two-way ANOVA with strain and sex as factors (B and C). Abbreviations: fBTBR (BTBR female mice); mBTBR (BTBR male mice); fC57 (C57 female mice); mC57 (C57 male mice). Data are shown as mean values ± SEM.

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