Figure 1: Movement of the PPDK domains.
From: Structural intermediates and directionality of the swiveling motion of Pyruvate Phosphate Dikinase
(a–c) Movement of the CD (yellow). (a) FtPPDK in PBD-facing conformation (PDB 5JVL/C). (b) FpPPDK (PDB 5JVN) with CD in an intermediate position. (c) TbPPDK (PDB 2X0S)19 with CD in NBD-facing conformation. (d-f) Movement of the NBD (the three subdomains are depicted by three different greens). (d) FtPPDK in nucleotide-unbound state (PDB 5JVJ/A). (e) FtPPDK in semi-closed, nucleotide-bound state (PDB 5JVL/C). (f) FtPPDK in fully closed, nucleotide-bound state (PDB 5JVL/A).
