Figure 2: Substrate binding sites of FtPPDK.
From: Structural intermediates and directionality of the swiveling motion of Pyruvate Phosphate Dikinase
(a) Semi-closed state of the PEP binding site (PDB 5JVL/A) with the catalytic H456 (yellow) pointing away from PEP. (b) Closed state of the PEP binding site (PDB 5JVL/C) revealing tight interactions between PEP and surrounding residues, including the catalytic H456 (yellow). (c) Closed state of the nucleotide binding site of 5JVL/D occupied with 2'-Br-dAppNHp. Interacting residues are highlighted.
