Figure 4: OCR and ECAR comparison of HME1 and MDA-MB-231 cells.
From: A platform for high-throughput bioenergy production phenotype characterization in single cells
(A) OCR single cell distribution shows a higher relative fraction of cells with OCR 0.8–4.8 fmoles/min with a lower fraction in the range of 0.2–0.6 fmoles/min in MDA-MB-231 cells; (B) Direct comparison of OCR values between HME and MDA-MB-231 cells shows a significant (p = 8.7·10−19, KS test) difference. The difference is more pronounced in the ECAR values as evidenced by the presence of larger ECAR values in MDA-MB-231 cells (C) and direct comparison of distribution parameters (D). (E) Comparison of combined OCR and ECAR between the two cell lines. While the majority of MDA-MB-231 cells show markedly higher ECAR values, a fraction of cells overlap with HME1 profile (blue dashed oval).
