Figure 6: Effects of cell-to-cell communication on the bioenergy production phenotype of MDA-MB-231 cells.
From: A platform for high-throughput bioenergy production phenotype characterization in single cells
While OCR showed a slight, but statistically significant reduction between wells with one and two cells (A), the ECAR (B) profile exhibited a strong, statistically significant (p < 0.05, KS two-sample test) decrease with increasing number of cells per well. (C) Single cell distributions of OCR and ECAR as a function of number of cells per well. Marked shift towards lower ECAR with the increased cell number per well can be seen. The tightening of the distributions due to averaging over increasing number of cells can be observed. The relative change in OCR and ECAR (D) suggest a relative shift to a more mitochondrial bioenergy production profile (higher relative OCR).
