Figure 3: LsIA N12 interactions at Ls-AChBP and the human α7, α3β2 and α3β4.
From: Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor
Residues constituting the interacting surface for LsIA N12 on Ls-AChBP as seen in the structure and the corresponding residues in α7, α3β2 and α3β4 are shown. The more extensive hydrophobic patch on α3β4 contributes to the enhanced affinity of the N12L analogue at this subtype.
