Figure 7: Prenatal to early postnatal treatment with P021 does not affect body weight and anxiety-like behavior in adult Ts65Dn mice. | Scientific Reports

Figure 7: Prenatal to early postnatal treatment with P021 does not affect body weight and anxiety-like behavior in adult Ts65Dn mice.

From: Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer’s-like memory deficits in the Ts65Dn mouse model of Down syndrome

Figure 7

(a) The monthly evaluation of body weight of study mice. The Ts65Dn mice weighed less than WT controls. No effect of P021 on body weight was observed. (b–d) Evaluation of anxiety-like behavior by measuring percentage of time spent in open arm (b), number of entries in open arm (c), and number of entries to all arms (d), in a 15 min-trial in elevated plus maze. Ts65Dn mice exhibited hyperactivity in the elevated plus maze. No effect of P021 treatment was observed. Data are presented as mean ± S.E.M. and are based on WT-V-WT (n = 10), WT-P-WT (n = 12), Dn-V-WT (n = 12), Dn-P-WT (n = 11), Dn-V-Dn (n = 13), and Dn-P-Dn (n = 12) mice. *p < 0.05; **p < 0.01***p < 0.001. One-way or two-way ANOVA with Bonferroni’s post-hoc test.

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