Figure 8: Prenatal to early postnatal treatment with P021 decreases spontaneous locomotor activity in adult Ts65Dn mice. | Scientific Reports

Figure 8: Prenatal to early postnatal treatment with P021 decreases spontaneous locomotor activity in adult Ts65Dn mice.

From: Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer’s-like memory deficits in the Ts65Dn mouse model of Down syndrome

Figure 8

(a–c) Ambulatory distance and time during 15 min-trials in the open field free exploration task. The locomotor activity was significantly increased in Ts65Dn mice as seen from increased ambulatory distance and time. Prenatal to early postnatal treatment with P021 significantly reduced these locomotion parameters. Data are presented as mean ± S.E.M. and are based on WT-V-WT (n = 10), WT-P-WT (n = 12), Dn-V-WT (n = 12), Dn-P-WT (n = 11), Dn-V-Dn (n = 13), and Dn-P-Dn (n = 12) mice. *p < 0.05; **p < 0.01***p < 0.001. One-way or two-way ANOVA with Bonferroni’s post-hoc test.

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