Table 2 Inhibitory effects of UA analogues UA-O-a~UA-O-j against α-glucosidase from baker’s yeast.

From: Synthesis and biological evaluation of novel ursolic acid analogues as potential α-glucosidase inhibitors

Compound code

R1

IC50 (μM)

Binding free energy (kcal/mol)

UA-O

—

2.47 ± 0.14

—

UA-O-a

1.17 ± 0.09

−3.866

UA-O-b

10.32 ± 0.55

−3.022

UA-O-c

7.49 ± 0.29

−2.959

UA-O-d

1.49 ± 0.14

−4.068

UA-O-e

3.22 ± 0.78

−4.084

UA-O-f

4.87 ± 0.41

−2.779

UA-O-g

7.87 ± 0.34

−4.058

UA-O-h

3.32 ± 0.17

−3.982

UA-O-i

0.71 ± 0.04

−3.512

UA-O-j

1.27 ± 0.20

−3.535

Back to article page