Figure 1: CXCR3 enables the establishment of metastatic-like melanoma in lungs.
From: CXCR3+ monocytes/macrophages are required for establishment of pulmonary metastases
Mice were intravenously injected with 3 × 105 B16F10 cells. (A) Expression of the melanocyte/melanoma-specific gene product tyrosinase in lungs in WT and CXCR3−/− mice, assessed 12d post-tumor challenge. (B) The number of visible lung metastases in WT and CXCR3−/− mice, assessed 12d post-tumor challenge. (C) Expression of tyrosinase in lungs of WT and CXCR3−/− mice, with or without tumor, assessed at 24 h post tumor-challenge. In gene expression experiments, qPCR data were normalized to GAPDH expression. Data are representative of two independent experiments with similar outcomes, with n = 7–10 mice/group in each study (Panels A and B) and n = 4–7 mice/group (Panel C). Differences were assessed by T-test as indicated: *p < 0.05; **p < 0.01; ****p < 0.0001.
