Figure 2: Removal of circulating monocytes ablates melanoma engraftment in the lung.
From: CXCR3+ monocytes/macrophages are required for establishment of pulmonary metastases
Mice were intravenously injected with 3 × 105 B16F10 cells. Some mice received a macrophage-depleting treatment (chlodronate-containing liposomes) prior to tumor injections. Engraftment was measured by relative expression of tyrosinase, normalized to GAPDH, 24 h post-injection of tumor. Data are representative of two independent experiments with similar outcomes, with n = 4–7 mice/group in each study. Differences were assessed by T-test as indicated: ****p < 0.0001.
