Figure 3: Tumor-induced accumulation of monocytes in lung is compromised in CXCR3−/− mice. | Scientific Reports

Figure 3: Tumor-induced accumulation of monocytes in lung is compromised in CXCR3−/− mice.

From: CXCR3+ monocytes/macrophages are required for establishment of pulmonary metastases

Figure 3

Mice were intravenously injected with 3 × 105 B16F10 cells. Twenty-four hours following B16F10 tumor injection, single cell suspensions of lungs were analyzed by flow cytometry. (A) Representative staining for circulatory-type monocytes (CD45+CD11b+Ly6C+) in lungs. Gated on viable CD45+ events. (B) Total numbers of lung monocytes. (C) Proportion of lung monocytes. Differences were assessed by T-test as indicated ***p < 0.001.

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