Figure 4: Phylogenetic and linkage analyses of the pretreatment and posttreatment HCV clones in non-SVR cases. | Scientific Reports

Figure 4: Phylogenetic and linkage analyses of the pretreatment and posttreatment HCV clones in non-SVR cases.

From: Evolution of multi-drug resistant HCV clones from pre-existing resistant-associated variants during direct-acting antiviral therapy determined by third-generation sequencing

Figure 4

Phylogenetic trees showing the pretreatment and posttreatment HCV clones with and without specific drug-resistant mutations (A. Case#1. B. Case#17. C. Case#4) Linkage of four synonymous nucleotide alterations (blue triangle) with T277C corresponding to amino acid Y93H (red triangle) (A and B), and C504G corresponding to amino acid D168E (red triangles) (C) are detectable in a subset of viral isolates at baseline and the majority of RAVs at treatment failure. In phylogenetic trees, orange dots show a subset of the pretreatment Y93H-positive clones with the synonymous nucleotide alterations that were detectable in the majority of RAVs at treatment failure (A and B). In Case#4, orange dots indicate a subset of the pretreatment D168E(C504G)-positive clones with the four synonymous nucleotide alterations that were detectable in the majority of RAVs at treatment failure (C).

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