Figure 4: The effect of EVs on the proliferation, apoptosis and osteogenesis of MSCs. | Scientific Reports

Figure 4: The effect of EVs on the proliferation, apoptosis and osteogenesis of MSCs.

From: Extracellular Vesicle-functionalized Decalcified Bone Matrix Scaffolds with Enhanced Pro-angiogenic and Pro-bone Regeneration Activities

Figure 4

(A) The proliferation of MSCs cultured in the presence of graded concentrations of EVs or PBS (control), n = 5. (B) Representative images of TUNEL assay. (C) Quantitative analysis of the percentage of TUNEL-positive cells. Three replicated slides for each group and five randomly selected views from each slide were analyzed, *p < 0.05. (D) qRT-PCR analysis of gene expression for Runx2, OPN, and OCN. Experiments were carried out on three samples for each group. NS, not significant at the level of 0.05.

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