Table 1 Representative list of proteins identified in NCCM and their functions.

From: Molecular Therapy for Degenerative Disc Disease: Clues from Secretome Analysis of the Notochordal Cell-Rich Nucleus Pulposus

S. No.

Accession Number

Protein Name-FASTA

Function/Cell Signaling

References

1

F1PW10_CANFA (+1)

Transforming Growth Factor Beta-1

Involved in development of notochord, Stimulates ECM synthesis

24,26

2

J9NTX8_CANFA

Connective Tissue Growth Factor

Involved in development of notochord, Stimulates ECM synthesis, Regulates TGFβ signaling

27, 28, 29, 30, 31

3

E2RJ75_CANFA

WNT1 Inducible Signaling Pathway Protein 2(CCN5)

Negatively regulates TGFβ signaling

32

4

F1PM26_CANFA

CD109

Negatively regulates TGFβ signaling

34, 35, 36

5

F6V790_CANFA

CILP

Regulates TGFβ signaling

37

6

PGS2_CANFA

Decorin

Negatively regulates TGFβ signaling

38

7

E2RJE0_CANFA [2]

Cartilage Oligomeric Matrix Protein1

Regulates TGFβ signaling

39

8

J9P9E4_CANFA

sclerostin (BMP antagonist)

Negatively regulates TGFβ signaling

40

9

E2RBE4_CANFA (+1)

Chordin

Negatively regulates TGFβ signaling

40

10

F1PY69_CANFA (+1)

Follistatin-Like Protein 1

Regulates TGFβ signaling

51

11

F6XL96_CANFA

Von Willebrand Factor A Domain-Containing Protein 1

Promotes matrix mineralization through TGFβ signaling

52

12

E2R612_CANFA

EGF-Containing Fibulin-Like Extracellular Matrix Protein

Regulates cell proliferation and apoptosis

53

13

E2RNR0_CANFA

Osteoglycin

Involved in muscle and bone linkage. Activates Samd3/4 independent of TGFβ.

54

14

E2R8H9_CANFA (+1)

pleiotrophin, Neurite Growth-Promoting Factor 11

Involved in Angiogenesis and neurite growth

55

15

F1P7Y6_CANFA

nidogen-2

Involved in ECM assembly, cell invasion, involved in Angiogenesis

56

16

F1PQV4_CANFA

Olfactomedin-Like 3

Binds to BMP4 enhances the canonical SMAD1/5/8 signaling pathway, involved in Angiogenesis

57

17

F1PN55_CANFA

Frizzled-Related Protein 1

Regulates Wnt signalling

41

18

E2R2G1_CANFA

Angiopoietin-Like 7

Involved in Angiogenesis

45

19

E2R0R3_CANFA

Semaphorin

Inhibits angiogenesis and nerve ingrowth in IVD

46,47

20

F1Q3G2_CANFA

Slit Homolog 3 (Drosophila)

Involved in Angiogenesis

58

21

E2RMA3_CANFA

Secreted Protein, Acidic, Cysteine-Rich (Osteonectin)

Involved in ECM assembly, invasion and proliferation

59

22

E2R161_CANFA (+1)

Secreted Phosphoprotein 1 (Osteopontin)

Involved in ECM composition, invasion and migration

59

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